The venue, home to BT Convention Centre and Echo Arena, is set to host 15 events next month alone.
A total of 10 events will take place, including many over several days, in the convention centre with five events in the arena.
It will be the busiest June in the past five years, with more than 45,000 visitors expected through the doors, generating over £20m in economic impact for the city.
Conferences include NHS Confederation, the British Association of Urological Surgeons, Royal College of Nursing and Unite. A selection of events will take place as part of the city's International Festival for Business such as Accelerate 2014 and Undersea Defence Technology (UDT).
Concerts taking place in June include Dolly Parton, The Eagles and Jason Derulo.
Bob Prattey, chief executive of ACC Liverpool, said: "June is always a particularly busy period for us with a series of large returning conferences such as The Royal College of Nursing, which alone will bring more than 4,000 delegates, and entertainment highlights including Once in a Lifetime featuring The Osmonds and David Essex.
"On top of this busy calendar, IFB is bringing in more opportunities such as UDT, which is a new defence sector for us to explore, and the return of Accelerate which will see thousands of entrepreneurs gathering in our venue.
"It will be an exciting period for visitors to our venue and to the city and we expect there to be a real buzz around the region.”