Called Hampton by Hilton, the hotel is located on the corner of Bond Street and York Street and forms a major conversion of what was York House, a 1960s office block.
Managed by Focus Hotels Management Ltd, it includes 186 bedrooms right in the heart of the city and is headed by general manager Imran Ali.
Creating 45 jobs and representing an investment of £20 million, the opening of the new hotel follows an increase in demand for quality rooms in Bristol as the city attracts more business and tourism.
The hotel will also provide much needed accommodation for those attending events once the building of the new arena near Temple Meads is complete.
Imran said: “It’s great to be open and I’d like to thank the Lord Mayor for officially opening this fantastic new venue.
“Our location on Bond Street and proximity to the bottom of the M32 and Cabot Circus makes this new hotel a key asset for the city.
“To bring back to life a building that had stood empty for many years is also good news for the city and will hopefully stimulate the regeneration of more buildings in the area.
“It’s vital that the city can provide suitable accommodation to any new visitors and to have a highly respected brand like Hampton by Hilton in the city centre helps cement its position as a leading player for business and leisure.”
Hampton is one of the brands of the Hilton Worldwide group. With more than 2,000 Hampton by Hilton hotels around the world they offers free hot breakfast and free wi-fi, as a standard.